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- Table of Contents
CARM1 Antibodies
AND CARM1 ELISA kits, CARM1 Proteins
Many biological assays use antibodies to detect CARM1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CARM1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CARM1 antibodies...
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CARM1 Infographic by Boster Bio
All CARM1 Products
Product
Figures
Specificity
Applications
Price
Human, Rat
Flow Cytometry, IF, ICC, WB
$370
Cat # PA2263
100 μg/vial
Cat # PA2263
100 μg/vial
Human, Monkey, Rat
ELISA, Flow Cytometry, IF, IHC, WB
$380
Cat # M01486-1
100ul
Cat # M01486-1
100ul
CARM1 Overview
Facts about Histone-arginine methyltransferase CARM1.
Histone-arginine methyltransferase CARM1 (CARM1)
Methylates (mono- and asymmetric dimethylation) that the guanidino nitrogens of arginyl residues in a number of proteins involved in DNA packaging, transcription regulation, pre-mRNA splicing, and mRNA stability. Recruited into promoters upon gene activation together with histone acetyltransferases from EP300/P300 and p160 households, methylates histone H3 at'Arg-17' (H3R17me), forming mainly asymmetric dimethylarginine (H3R17me2a), leading to activate transcription through chromatin remodeling.
Throughout myogenic transcriptional activation, acts together with NCOA3/ACTR as a coactivator for MEF2C. Throughout monocyte inflammatory stimulation, acts together with EP300/P300 as a coactivator for NF-kappa-B.
Gene Information
| Human | |
|---|---|
| Gene Name: | CARM1 |
| Uniprot: | Q86X55 |
| Entrez: | 10498 |
Family
| Belongs to: |
|---|
| class I-like SAM-binding methyltransferase superfamily |
Alternative Names
Carm1; coactivator-associated arginine methyltransferase 1EC 2.1.1.-; EC 2.1.1; histone-arginine methyltransferase CARM1; PRMT4; PRMT4EC 2.1.1.125; Protein arginine N-methyltransferase 4
Molecular Weight
Mass (kDA):
65.854 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 19p13.2 |
| Sequence: | 19; NC_000019.10 (10871553..10923078) |
Tissue Specificity
Overexpressed in prostate adenocarcinomas and high-grade prostatic intraepithelial neoplasia.
Subcellular Localizations
Nucleus. Cytoplasm. Mainly nuclear during the G1, S and G2 phases of the cell cycle. Cytoplasmic during mitosis, after breakup of the nuclear membrane.
Diseases
- Malignant Neoplasms
- Neoplasms
- Mammary Neoplasms
- Malignant Neoplasm Of Breast
- Malignant Neoplasm Of Prostate
- Prostatic Neoplasms
- Spinal Muscular Atrophy
- Atrophy
- Cell Transformation, Neoplastic
- Muscular Atrophy
- Leukemia
- Neuromuscular Diseases
- Hypoxia
Interacting Proteins
- CEBPB
- DNAJA3
- JMJD6
- NCOA3
- NUDT21
- QKI
- SMARCC1
Pathways
- Methylation
- Histone Methylation
- Cell Cycle
- Localization
- Chromatin Remodeling
- Cell Proliferation
- Regulation Of Gene Expression
- Cell Differentiation
- Protein Methylation
- Histone Modification
- Dna Repair
- Histone Arginine Methylation
- Cell Growth
PTMs
- Methylation
- Acetylation
- Phosphorylation
- Reduction
- Cleavage
Research Areas
- Cancer
- Cellular Markers
- Transcription Factors and Regulators
- Tumor Suppressors
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CARM1
bosterbio.com/bosterbio-gene-info-cards/CARM1
References
PMID: 12237300 by Li H., et al. Lipopolysaccharide-induced methylation of HuR, an mRNA-stabilizing protein, by CARM1. Coactivator-associated arginine methyltransferase.
PMID: 15221992 by Hong H., et al. Aberrant expression of CARM1, a transcriptional coactivator of androgen receptor, in the development of prostate carcinoma and androgen-independent status.