CARMIL1 Antibodies

AND CARMIL1 ELISA kits, CARMIL1 Proteins

Many biological assays use antibodies to detect CARMIL1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CARMIL1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CARMIL1 antibodies...

We validate the specificity of these antibodies to CARMIL1 by testing them on tissues known to express CARMIL1 positively and negatively. Browse below to find the CARMIL1 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CARMIL1 Infographic by Boster Bio

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CARMIL1 Overview

Facts about F-actin-uncapping protein LRRC16A.

CARMIL1 3D structure. Source: alphafold

F-actin-uncapping protein LRRC16A (CARMIL1)

Cell membrane-cytoskeleton-associated protein which plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization, however, seems unable to nucleate filaments (PubMed:16054028).

Plays a role in lamellipodial protrusion formations and cell migration (PubMed:19846667). .

Gene Information

Human
Gene Name:	CARMIL1
Uniprot:	Q5VZK9
Entrez:	55604

Family

Belongs to:

CARMIL family

Alternative Names

F-actin-uncapping protein LRRC16A

Molecular Weight

Mass (kDA):
151.557 kDA

Genomic Context


Human

Location:	6p22.2
Sequence:	6; NC_000006.12 (25279374..25620530)

Tissue Specificity

Expressed in lung, placenta, small intestine, liver, thymus, colon, skeletal muscle, heart and brain. Higher expression in kidney.

Subcellular Localizations

Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane. Cell projection, lamellipodium. Found on macropinosomes (PubMed:19846667). Colocalized with heterodimeric capping protein (CP) and F-actin in lamellipodia but not with F-actin in stress fibers (PubMed:19846667).

PTMs

Acetylation

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CARMIL1

References

PMID: 19846667 by Liang Y., et al. Distinct roles for CARMIL isoforms in cell migration.

PMID: 16054028 by Yang C., et al. Mammalian CARMIL inhibits actin filament capping by capping protein.