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- Table of Contents
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Facts about Caspase-9.
Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent method. Proteolytically cleaves poly(ADP- ribose) polymerase (PARP).
Human | |
---|---|
Gene Name: | CASP9 |
Uniprot: | P55211 |
Entrez: | 842 |
Belongs to: |
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peptidase C14A family |
APAF-3APAF3; apoptotic protease activating factor 3; Apoptotic protease Mch-6; Apoptotic protease-activating factor 3; CASP9; CASP-9; caspase 9, apoptosis-related cysteine peptidase; Caspase9; Caspase-9; EC 3.4.22.62; ICE-LAP6CASPASE-9c; ICE-like apoptotic protease 6; MCH6apoptosis-related cysteine protease
Mass (kDA):
46.281 kDA
Human | |
---|---|
Location: | 1p36.21 |
Sequence: | 1; NC_000001.11 (15491401..15524912, complement) |
Ubiquitous, with highest expression in the heart, moderate expression in liver, skeletal muscle, and pancreas. Low levels in all other tissues. Within the heart, specifically expressed in myocytes.
The Boster Bio optimizer is a great way to optimize experiments and get the most out of your biological samples. This guide will help you make informed decisions about the best settings and improve results. Almost every experiment runs into trouble at some point. While there are several sources of error, proper controls can eliminate them. Troubleshooting guides are essential for identifying and addressing these problems.
Optimisation tips for Boster Bio's recombinant enzymes are available at www.bosterbio.com/bestusesofthecsp9-marker.pdf. Use these guides to make informed decisions regarding your experiments, and optimize your results. Every researcher runs into problems while conducting experiments, and a good troubleshooting guide can help you identify common sources of error.
The CASP9 marker is a genetic variation that is highly correlated with lung cancer risk. Its polymorphisms are linked to tobacco smoking, while there is no such association in patients who never smoke. Molecular genetics studies are necessary to confirm these findings in diverse ethnic groups. The markers can also be used in research to test the mutagenesis potential of various plant species. However, many of these markers still remain scarce.
PMID: 8663294 by Duan H., et al. ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B.
PMID: 8900201 by Srinivasula S.M., et al. The Ced-3/interleukin 1beta converting enzyme-like homolog Mch6 and the lamin-cleaving enzyme Mch2alpha are substrates for the apoptotic mediator CPP32.
*Showing only the more recent 20. More publications can be found for each product on its corresponding product page