Caspase-9 (CASP9)

Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf- 1 leads to activation of the protease which then cleaves and activates caspase-3.

Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent method. Proteolytically cleaves poly(ADP- ribose) polymerase (PARP).