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- Table of Contents
CASR Antibodies
AND CASR ELISA kits, CASR Proteins
Many biological assays use antibodies to detect CASR, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CASR in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CASR antibodies...
Designing a Western blot for CASR? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the CASR Western Blot GuideCASR Infographic by Boster Bio
All CASR Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IHC, WB
$370
Cat # PB9924
100 μg/vial
Cat # PB9924
100 μg/vial
Human, Mouse, Rat
ELISA
$540
Cat # EKC2220
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2220
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$480
Cat # EKC1072
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1072
1 kit, containing one 96-well plate and all necessary reagents
Human
$628
Cat # LS000846
20 µg, 100 µg
Cat # LS000846
20 µg, 100 µg
CASR Overview
Facts about Extracellular calcium-sensing receptor.
Extracellular calcium-sensing receptor (CASR)
G-protein-coupled receptor that senses changes in the extracellular concentration of calcium ions and plays a key role in maintaining calcium homeostasis (PubMed:7759551, PubMed:8702647, PubMed:8636323, PubMed:8878438, PubMed:17555508, PubMed:19789209, PubMed:21566075, PubMed:22114145, PubMed:23966241, PubMed:25292184, PubMed:25104082, PubMed:26386835, PubMed:25766501, PubMed:22789683). Senses changes from the circulating calcium concentration and modulates the production of parathyroid hormone (PTH) in adrenal glands (By similarity).
The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol- calcium second messenger system (PubMed:7759551). The G-protein- coupled receptor activity is activated by a co-agonist mechanism: aromatic amino acids, such as Trp or Phe, act concertedly with divalent cations, such as calcium or magnesium, to attain whole receptor activation (PubMed:27434672, PubMed:27386547).
Gene Information
| Human | |
|---|---|
| Gene Name: | CASR |
| Uniprot: | P41180 |
| Entrez: | 846 |
Family
| Belongs to: |
|---|
| G-protein coupled receptor 3 family |
Alternative Names
calcium-sensing receptor; CAR; CaSR; EIG8; extracellular calcium-sensing receptor; FHH; FIH; GPRC2A; GPRC2AHHC; HHC1; hypocalciuric hypercalcemia 1; NSHPT; parathyroid Ca(2+)-sensing receptor 1; Parathyroid cell calcium-sensing receptor; PCaR1; PCAR1MGC138441
Molecular Weight
Mass (kDA):
120.675 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 3q13.33-q21.1 |
| Sequence: | 3; NC_000003.12 (122183668..122291629) |
Tissue Specificity
Expressed in the temporal lobe, frontal lobe, parietal lobe, hippocampus, and cerebellum. Also found in kidney, lung, liver, heart, skeletal muscle, placenta.
Subcellular Localizations
Cell membrane; Multi-pass membrane protein.
Diseases
- Hypercalcemia
- Familial Hypocalciuric Hypercalcaemia
- Hypocalcemia
- Hyperparathyroidism, Primary
- Malignant Neoplasms
- Hypoparathyroidism
- Hyperparathyroidism, Secondary
- Neoplasms
- Hyperplasia
- Hypercalciuria
- Adenoma
- Carcinoma
Interacting Proteins
- TMED2
Pathways
- Secretion
- Excretion
- Transport
- Pathogenesis
- Localization
- Cell Proliferation
- Hormone Secretion
- Parathyroid Hormone Secretion
- Bone Remodeling
- Bone Resorption
- Cell Cycle
- Cell Growth
- Ion Transport
PTMs
- Phosphorylation
- Glycosylation
- Cleavage
- Methylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CASR
bosterbio.com/bosterbio-gene-info-cards/CASR
References
PMID: 8813042 by Pearce S.H.S., et al. A familial syndrome of hypocalcemia with hypercalciuria due to mutations in the calcium-sensing receptor.
PMID: 7759551 by Garrett J.E., et al. Molecular cloning and functional expression of human parathyroid calcium receptor cDNAs.
2 Publications of Boster CASR Antibodies & ELISA Kits
- PubMed ID: -, Wouter H. van Megen,Rebecca Tan,R. Todd Alexander,Henrik Dimke bioRxiv 2021.02.0...
- PubMed ID: 28674286, Yuan, H., Shi, Y., Li, Y., Yang, L., Tang, Y., Hu, Z.,…, & Tang, C. (2017). Ev...
*More publications can be found for each product on its corresponding product page