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Protein CBFA2T3 Antibodies
AND CBFA2T3 ELISA kits, Protein CBFA2T3 Proteins
Many biological assays use antibodies to detect Protein CBFA2T3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Protein CBFA2T3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Protein CBFA2T3 antibodies...
Designing an IHC experiment for Protein CBFA2T3? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the CBFA2T3 IHC GuideCBFA2T3 Infographic by Boster Bio
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CBFA2T3 Overview
Facts about Protein CBFA2T3.
Protein CBFA2T3 (CBFA2T3)
Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of additional corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199). Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453).
Reduces the protein levels and stability of the transcriptinal regulator HIF1A; interacts with EGLN1 and promotes the HIF1A prolyl hydroxylation-dependent ubiquitination and proteasomal degradation pathway (PubMed:25974097). Contributes to inhibition of glycolysis and stimulation of mitochondrial respiration by down-regulating the expression of glycolytic genes including PFKFB3, PFKFB4, PDK1, PFKP, LDHA and HK1 which are direct targets of HIF1A (PubMed:23840896, PubMed:25974097).
Gene Information
| Human | |
|---|---|
| Gene Name: | CBFA2T3 |
| Uniprot: | O75081 |
| Entrez: | 863 |
Family
| Belongs to: |
|---|
| CBFA2T family |
Alternative Names
core-binding factor, runt domain, alpha subunit 2; translocated to, 3; hMTG16; MTG16ETO2; MTG8-related protein 2; MTGR2MTG8-related gene 2; Myeloid translocation gene on chromosome 16 protein; protein CBFA2T3; Zinc finger MYND domain-containing protein 4; ZMYND4myeloid translocation gene 8 and 16b
Molecular Weight
Mass (kDA):
71.192 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 16q24.3 |
| Sequence: | 16; NC_000016.10 (88874858..88977207, complement) |
Tissue Specificity
Widely expressed with higher expression in heart, pancreas, skeletal muscle, spleen, thymus and peripheral blood leukocytes. Expressed in hematopoietic cells (at protein level).
Subcellular Localizations
[Isoform 1]: Nucleus, nucleolus. The RUNX1-CBFA2T3 fusion protein localizes to the nucleoplasm.; [Isoform 2]: Nucleus, nucleoplasm. Golgi apparatus membrane.
Diseases
- Leukemia
- Myeloid Leukemia
- Leukemia, Myelocytic, Acute
- Malignant Neoplasms
- Neoplasms
- Mammary Neoplasms
- Chromosomal Translocation
- Malignant Neoplasm Of Breast
- Cell Transformation, Neoplastic
- Nervousness
- Carcinoma
- T(8;21)(q22;q22)
- Lymphoma
Interacting Proteins
- PLXNA3
- ZNF652
Pathways
- Localization
- Pathogenesis
- Cell Proliferation
- Methylation
- Cell Differentiation
- Oncogenesis
- Granulocyte Differentiation
- Cell Activation
- Response To Wounding
- Camp-mediated Signaling
- T Cell Activation
- Erythrocyte Differentiation
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CBFA2T3
bosterbio.com/bosterbio-gene-info-cards/CBFA2T3
References
PMID: 9596646 by Gamou T., et al. The partner gene of AML1 in t(16;21) myeloid malignancies is a novel member of the MTG8(ETO) family.
PMID: 9790752 by Calabi F., et al. CBFA2T1, a gene rearranged in human leukemia, is a member of a multigene family.