Coiled-coil domain-containing protein 115 (Ccdc115)

Accessory part of this proton-transporting vacuolar (V)-ATPase protein pump involved in intracellular iron homeostasis. In aerobic conditions, required for intracellular iron homeostasis, thus triggering the action of Fe(2+) prolyl hydroxylase (PHD) enzymes, and resulting in HIF1A hydroxylation and subsequent proteasomal degradation.

Necessary for endolysosomal acidification and lysosomal degradation (By similarity). May be involved in Golgi homeostasis (By similarity).