Protein KASH5 (Ccdc155)

As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the Link between the nuclear lamina and the cytoskeleton.

The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning.

Required for telomere attachment to nuclear envelope in the prophase of meiosis and for rapid telomere prophase movements implicating a SUN1/2:KASH5 LINC complex in which SUN1 and SUN2 seem to act at least partial redundantly. Required for homologue pairing during meiotic prophase in spermatocytes and probably oocytes.