CCDC40 Antibodies

AND CCDC40 ELISA kits, CCDC40 Proteins

Many biological assays use antibodies to detect CCDC40, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CCDC40 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CCDC40 antibodies...

We validate the specificity of these antibodies to CCDC40 by testing them on tissues known to express CCDC40 positively and negatively. Browse below to find the CCDC40 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CCDC40 Infographic by Boster Bio

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CCDC40 Overview

Facts about Coiled-coil domain-containing protein 40.

CCDC40 3D structure. Source: alphafold

Coiled-coil domain-containing protein 40 (CCDC40)

Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella (PubMed:21131974). Probably acts together with CCDC39 to form a molecular ruler that decides the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella (By similarity).

Not required for outer dynein arm complexes assembly. Required for axonemal recruitment of CCDC39 (PubMed:21131974).

Gene Information

Human
Gene Name:	CCDC40
Uniprot:	Q4G0X9
Entrez:	55036

Family

Belongs to:

CCDC40 family

Alternative Names

Coiled-coil domain-containing protein 40

Molecular Weight

Mass (kDA):
130.113 kDA

Genomic Context


Human

Location:	17q25.3
Sequence:	17; NC_000017.11 (80036632..80100613)

Subcellular Localizations

Cytoplasm. Cell projection, cilium. Localizes to cytoplasm and motile cilium.

Diseases

Ciliary dyskinesia, primary, 15 (CILD15)

PTMs

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CCDC40

References

PMID: 21131974 by Becker-Heck A., et al. The coiled-coil domain containing protein CCDC40 is essential for motile cilia function and left-right axis formation.

PMID: 22693285 by Blanchon S., et al. Delineation of CCDC39/CCDC40 mutation spectrum and associated phenotypes in primary ciliary dyskinesia.