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- Table of Contents
Facts about CMRF35-like molecule 8.
.
Human | |
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Gene Name: | CD300A |
Uniprot: | Q9UGN4 |
Entrez: | 11314 |
Belongs to: |
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CD300 family |
CD300a antigenCMRF35H9; CD300a molecule; CD300a; CLM8; CLM-8; CMRF35H leukocyte immunoglobulin-like receptor; CMRF-35H; CMRF35-H; CMRF35-H9; CMRF-35-H9CD300 antigen-like family member A; CMRF35HIRp60; CMRF35-like molecule 8; IGSF12; IGSF12NK inhibitory receptor; Immunoglobulin superfamily member 12; Inhibitory receptor protein 60; IRC1; IRC1/IRC2; IRC2; IRp60; leukocyte membrane antigen; LMIR1; MAIR-I; Mcipr1; NKRL; Pigr4
Mass (kDA):
33.201 kDA
Human | |
---|---|
Location: | 17q25.1 |
Sequence: | 17; NC_000017.11 (74466373..74484798) |
Expressed not only by natural killer (NK) cells but also by T-cell subsets, B-cells, dendritic cells, mast cells, granulocytes and monocytes.
Cell membrane; Single-pass type I membrane protein.
Steven Boster is probably a familiar name. But have you heard of the high-affinity primary antibodies? If not, you need to. These antibodies are the foundation for high-quality research. They are also frequently cited within the research community. Boster Bio is a good place to start if you are looking for a high-affinity CD300A antibody.
Steven Boster was the inventor of his first product, a series containing highly sensitive and specific antibodies. Boster's technology and methods have been refined over the past two decades. Products have been cited in over 29,000 publications. Boster's line of antibodies has been validated for use in IHC and WB. These primary antibodies have unmatched sensitivity and specificity.
Flow Cytometry has many applications in science. It requires cells or particles to be analysed. Boster provides high-affinity primary antibodies, monoclonal or multiclonal. These antibodies are extremely useful for research and have been cited numerous times. Boster is a leader in high-affinity primary antibody research, with over a thousand patents.
The company offers a variety ELISA tests to detect a wide array of proteins and hormones. These include cytokines (small molecules), and oxidative strain. Boster's ELISA reagent kits provide enough reagents that they can perform 96 tests. They are available in several formats for different applications, including IHC, WB, and IP. Boster high-affinity prima antibodies can also detect cellular parts, such as cells that are expressing certain hormones.
OAS theory suggests new influenza viruses could escape surveillance if the immune system is dominated by memory B cells. Five donors were tested for antibodies to B/Malaysia/2506/2004 & B/Hong Kong/33/2001 in the 2006/7 flu season. In 2005/6, the fifth donor received vaccinations. A 1991 donor was also part of the study.
The principles of enzyme–linked immunosorbent asays (ELISAs), work in a similar way to other immunoassay methods. Specific antibodies bind to a target antibody and the detection system determines whether it has bound to the antigen. Boster Bio is trusted around the world by scientists due to its high-affinity antibodies.
These tests show exceptional antigen-specificity thanks to the use of recombinant proteins. The antibodies are stable in large quantities and don't show any cell-line drift. They are also derived from the same animal sources as the bovine saline. Moreover, they have low non-specific cross-reactivity. In addition to being highly specific, these antibodies are extremely useful in research and clinical applications. When used in appropriate dosages, they are highly effective in reducing infectious doses of virus in tissue cultures.
These high-affinity primaries antibodies are made by utilizing animals' immune systems. They are made of proteins called complementarity-determining regions. This complex topic is covered in detail on the Wikipedia page. Scientists create polyclonal primary antibodies by immunizing hosts with a variety antigens and then separating the antibodies from the host egg or serum. The antigens are then examined to confirm that they are bound.
This antibody is highly specific to CD300F (a molecule expressed in human mast cells). The CD300F mAb recognizes the protein and mediated cell death in a mouse model independent of caspases, ITIMs, or PI3K activity. These results suggest that CD300f may have the same property in humans. However, further studies are needed to confirm the hypothesis.
PMID: 10540326 by Cantoni C., et al. Molecular and functional characterization of IRp60, a member of the immunoglobulin superfamily that functions as an inhibitory receptor in human NK cells.
PMID: 9701027 by Green B.J., et al. The CMRF-35 mAb recognizes a second leukocyte membrane molecule with a domain similar to the poly Ig receptor.