CMRF35-like molecule 8 Antibodies

AND CD300A ELISA kits, CMRF35-like molecule 8 Proteins

Many biological assays use antibodies to detect CMRF35-like molecule 8, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CMRF35-like molecule 8 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CMRF35-like molecule 8 antibodies...

We validate the specificity of these antibodies to CMRF35-like molecule 8 by testing them on tissues known to express CD300A positively and negatively. Browse below to find the CD300A antibody that suites your experiment. We have 6 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Previous: SEPTIN9 Next: RBPJL

CD300A Infographic by Boster Bio

All CD300A Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Human CD300A ELISA Kit PicoKine®

6 Q&As

Human

ELISA

$750
Cat # EK1980
96 wells/kit, with removable strips.

Anti-Hu CD300a Purified Monoclonal Antibody

Human

Flow Cytometry, WB

$308
Cat # M05953
0.1 mg

Anti-CMRF35-like molecule 8 CD300a Antibody

Human

ELISA, WB

$380
Cat # A05953
100ul

Human CD300a/LMIR1 Recombinant Protein

SDS-PAGE

$250
Cat # PROTQ9UGN4
Starting from 10ug

CD300 antigen (CD300A) (NM_007261) Human Over-expression Lysate

Human

$628
Cat # LS011314
100 µg

Anti-CD300A Antibody Picoband®

Human, Mouse, Rat

ELISA, Flow Cytometry, WB

$370
Cat # A05953-1
100 µg/vial

CD300A Overview

Facts about CMRF35-like molecule 8.

CD300A 3D structure. Source: alphafold

CMRF35-like molecule 8 (CD300A)

Inhibitory receptor which might lead to the down- regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation (PubMed:10746781, PubMed:16339535, PubMed:9701027). Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 although not TRIF through activation of PTPN6 (PubMed:22043923).

Gene Information

Human
Gene Name:	CD300A
Uniprot:	Q9UGN4
Entrez:	11314

Family

Belongs to:

CD300 family

Alternative Names

CD300a antigenCMRF35H9; CD300a molecule; CD300a; CLM8; CLM-8; CMRF35H leukocyte immunoglobulin-like receptor; CMRF-35H; CMRF35-H; CMRF35-H9; CMRF-35-H9CD300 antigen-like family member A; CMRF35HIRp60; CMRF35-like molecule 8; IGSF12; IGSF12NK inhibitory receptor; Immunoglobulin superfamily member 12; Inhibitory receptor protein 60; IRC1; IRC1/IRC2; IRC2; IRp60; leukocyte membrane antigen; LMIR1; MAIR-I; Mcipr1; NKRL; Pigr4

Molecular Weight

Mass (kDA):
33.201 kDA

Genomic Context


Human

Location:	17q25.1
Sequence:	17; NC_000017.11 (74466373..74484798)

Tissue Specificity

Expressed not only by natural killer (NK) cells but also by T-cell subsets, B-cells, dendritic cells, mast cells, granulocytes and monocytes.

Subcellular Localizations

Cell membrane; Single-pass type I membrane protein.

Diseases

Inflammation
Allergy
Anaphylaxis
Chronic Eosinophilic Inflammation
Leukemia
Cutaneous Anaphylaxis (disorder)
Cholangiocarcinoma
Tetanus
Polyps
Ulcer
Immunologic Deficiency Syndromes
Neoplasm, Residual

Neoplasms
Asthma
L1 Acute Lymphoblastic Leukemia
Diarrhea
Peritonitis
Hay Fever
Eosinophilia

Interacting Proteins

KRT38

Pathways

Basophil Degranulation
Anaphylaxis
Phagocytosis
Eosinophil Activation
Signal Transmission
Immune Response
Fibroblast Proliferation
Conjugation
Macrophage Activation
Mast Cell Degranulation

Cell Death
Tissue Remodeling
Basophil Activation
Secretion

PTMs

Phosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CD300A

References

PMID: 10540326 by Cantoni C., et al. Molecular and functional characterization of IRp60, a member of the immunoglobulin superfamily that functions as an inhibitory receptor in human NK cells.

PMID: 9701027 by Green B.J., et al. The CMRF-35 mAb recognizes a second leukocyte membrane molecule with a domain similar to the poly Ig receptor.