CMRF35-like molecule 3 Antibodies

AND Cd300ld3 ELISA kits, CMRF35-like molecule 3 Proteins

Many biological assays use antibodies to detect CMRF35-like molecule 3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CMRF35-like molecule 3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CMRF35-like molecule 3 antibodies...

We validate the specificity of these antibodies to CMRF35-like molecule 3 by testing them on tissues known to express Cd300ld3 positively and negatively. Browse below to find the Cd300ld3 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Cd300ld3 Infographic by Boster Bio

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Cd300ld3 Overview

Facts about CMRF35-like molecule 3.

Cd300ld3 3D structure. Source: alphafold

CMRF35-like molecule 3 (Cd300ld3)

Acts as an activating receptor inducing cytokine production in mast cells. Can function as a positive regulator of TLR9 signaling in macrophages, leading to enhanced production of proinflammatory cytokines.

Gene Information

Mouse
Gene Name:	Cd300ld3
Uniprot:	Q6SJQ5
Entrez:	382551

Family

Belongs to:

CD300 family

Alternative Names

CMRF35-like molecule 3

Molecular Weight

Mass (kDA):
27.312 kDA

Genomic Context


Mouse

Location:	11\|11 E2
Sequence:	11;

Tissue Specificity

Highly expressed in bone marrow-derived mast cells and macrophages, peripheral blood monocytes and CD11c+ cells, with weaker expression detected in CD11b cells in bone marrow and peripheral blood. Not detected in B220+ cells in bone marrow or spleen, in Thy-1.2+ or CD3+ cells in peripheral blood, spleen or thymus, or in NK1.1+ cells in spleen (at protein level). Widely expressed in various tissues including heart, liver, spleen, lung, kidney, brain, bone marrow, thymus, axillary lymph node and mesenteric lymph node. Highly expressed in macrophage cell lines J774.1 and RAW 264.7 and in mast cell line MC/9. Weak expression detected in B-lineage cell lines WEHI-231 and A20 and in dendritic cell line DC2.4. Not detected in other myeloid cell lines or T-lineage cell lines.

PTMs

Disulfide bond

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Cd300ld3

References

PMID: 14662855 by Chung D.-H., et al. CMRF-35-like molecule-1, a novel mouse myeloid receptor, can inhibit osteoclast formation.

PMID: 20817736 by Enomoto Y., et al. Characterization of leukocyte mono-immunoglobulin-like receptor 7 (LMIR7)/CLM-3 as an activating receptor: its similarities to and differences from LMIR4/CLM-5.