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- Table of Contents
Facts about CDC42 small effector protein 2.
In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages.
Human | |
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Gene Name: | CDC42SE2 |
Uniprot: | Q9NRR3 |
Entrez: | 56990 |
Belongs to: |
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CDC42SE/SPEC family |
CDC42 small effector 2; FLJ21967; non-kinase Cdc42 effector protein SPEC2; Small effector of CDC42 protein 2; SPEC2CDC42 small effector protein 2
Mass (kDA):
9.223 kDA
Human | |
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Location: | 5q31.1 |
Sequence: | 5; NC_000005.10 (131264053..131394672) |
Widely expressed. Expressed at higher level in T-lymphocytes. Highly expressed in CCRF-CEM T-lymphocytes, Jurkat T-lymphocytes, and Raji B-lymphocytes compared (at protein level).
Cytoplasm, cytoskeleton. Cell membrane; Lipid-anchor. Cell projection, phagocytic cup. Recruited to the activated TCR prior actin polymerization. Localizes at the phagocytic cup of macrophages.
PMID: 10816584 by Pirone D.M., et al. SPECs, small binding proteins for Cdc42.
PMID: 15840583 by Ching K.H., et al. The role of SPECs, small Cdc42-binding proteins, in F-actin accumulation at the immunological synapse.