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Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1. .
|Sequence:||7; NC_000007.14 (21900899..21945899, complement)|
Ubiquitous. Overexpressed in medulloblastoma.
Cytoplasm. Nucleus. Associates with chromatin. Translocates from cytoplasm to nucleus under dexamethasone induction.