- Table of Content
Specifically activates exon 5 inclusion of TNNT2 in embryonic, but not mature, skeletal muscle. Activates TNNT2 exon 5 inclusion by antagonizing the repressive effect of PTB.
|Sequence:||10; NC_000010.11 (10462515..11336675)|
Expressed in frontal cortex. Isoform 1 is expressed in brain and lung. Isoform 2 is expressed in heart, brain, placenta, lung, liver, kidney, skeletal muscle and pancreas. Isoform 4 is expressed in heart, lung, skeletal muscle, kidney and pancreas.
Nucleus. Cytoplasm. Accumulates in the cytoplasm after ionizing radiation (By similarity). Colocalizes with APOBEC1 and A1CF. RNA-binding activity is detected in both nuclear and cytoplasmic compartments.