Centromere protein W (Cenpw)

Part of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation (By similarity). The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complicated and may be involved in incorporation of newly synthesized CENPA into centromeres (By similarity).

Section of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Part of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an significant role in kinetochore assembly.