Centrosomal protein of 164 kDa (CEP164)

Plays a role in microtubule organization and/or upkeep for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface of epithelial cells. Plays a crucial role in G2/M checkpoint and nuclear divisions.

A vital player in the DNA damage-activated ATR/ATM signaling cascade because it is required for the correct phosphorylation of H2AX, RPA, CHEK2 and CHEK1. Plays a crucial role in chromosome segregation, acting as a mediator necessary for the maintenance of genomic stability through modulation of MDC1, RPA and CHEK1.