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A vital player in the DNA damage-activated ATR/ATM signaling cascade because it is required for the correct phosphorylation of H2AX, RPA, CHEK2 and CHEK1. Plays a crucial role in chromosome segregation, acting as a mediator necessary for the maintenance of genomic stability through modulation of MDC1, RPA and CHEK1.
|Sequence:||11; NC_000011.10 (117316346..117413266)|
Expressed in several cell lines.
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Nucleus. Localizes specifically to very distally located appendage structures on the mature centriole from which initiate PC formation (PubMed:26337392). Persisted at centrioles throughout mitosis. Expressed in chromatin-enriched nuclear fraction of HeLa cells. In response to DNA damage, it translocates to nuclear foci that contain the DNA damage response proteins KAT5/TIP60 and CHEK1.