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- Table of Contents
Facts about Centrosomal protein of 85 kDa-like.
Human | |
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Gene Name: | CEP85L |
Uniprot: | Q5SZL2 |
Entrez: | 387119 |
Belongs to: |
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CEP85 family |
bA57K17.2; C6orf204; centrosomal protein 85kDa-like; CEP85L; chromosome 6 open reading frame 204; NY-BR-15; RP11-57K17.2; serologically defined breast cancer antigen NY-BR-15
Mass (kDA):
91.808 kDA
Human | |
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Location: | 6q22.31 |
Sequence: | 6; NC_000006.12 (118460772..118710101, complement) |
Isoform 1 and isoform 4 are expressed in spleen, lymph, thymus, tonsil and peripheral blood leukocytes, with isoform 1 expressed at higher levels. Isoform 4 is detected in K-562 leukemia cells and in the blood of precursor T lymphoblastic lymphoma (T-ALL) patients.
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Subcellular experiments using a GFP-tagged system produced a weak signal, rendering it difficult to confirm centrosome association.
PMID: 21938754 by Chmielecki J., et al. Systematic screen for tyrosine kinase rearrangements identifies a novel C6orf204-PDGFRB fusion in a patient with recurrent T-ALL and an associated myeloproliferative neoplasm.
PMID: 12747765 by Scanlan M.J., et al. Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression.