Ceramide kinase Antibodies

AND CERK ELISA kits, Ceramide kinase Proteins

Many biological assays use antibodies to detect Ceramide kinase, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Ceramide kinase in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Ceramide kinase antibodies...

We validate the specificity of these antibodies to Ceramide kinase by testing them on tissues known to express CERK positively and negatively. Browse below to find the CERK antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CERK Infographic by Boster Bio

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CERK Overview

Facts about Ceramide kinase.

CERK 3D structure. Source: alphafold

Ceramide kinase (CERK)

Catalyzes especially the phosphorylation of ceramide to form ceramide 1-phosphate. Acts efficiently on analog and natural ceramides (C6, C8, C16 ceramides, and C8-dihydroceramide), to a lesser extent on C2-ceramide and C6-dihydroceramide, but not on other lipids, such as many sphingosines.

Binds phosphoinositides. .

Gene Information

Human
Gene Name:	CERK
Uniprot:	Q8TCT0
Entrez:	64781

Family

Belongs to:

No superfamily

Alternative Names

ceramide kinase; dA59H18.2; DKFZp434E0211; EC 2.7.1.138; FLJ21430; FLJ23239; hCERKLipid kinase 4; KIAA1646dA59H18.3; lipid kinase LK4; LK4Acylsphingosine kinase; MGC131878

Molecular Weight

Mass (kDA):
59.977 kDA

Genomic Context


Human

Location:	22q13.31
Sequence:	22; NC_000022.11 (46684410..46738252, complement)

Subcellular Localizations

Cytoplasm. Cell membrane; Peripheral membrane protein.

Diseases

Inflammation
Neoplasms
Retinal Degeneration
Malignant Neoplasms
Growth Arrest
Malignant Neoplasm Of Breast
Acute Basophilic Leukemia
Immediate Hypersensitivity
Carcinogenesis
Insulin Resistance
Cardiovascular Diseases
Edema

Tumor Angiogenesis
Asthma
Allergy
Mammary Neoplasms
Impaired Glucose Tolerance
Pathologic Neovascularization

Interacting Proteins

ALAS1
MTUS2
NOTCH2NL

Pathways

Localization
Cell Growth
Phagocytosis
Mast Cell Degranulation
Transport
Ceramide Transport
Cell Proliferation
Membrane Fusion
Cell Cycle
Macrophage Activation
Cell Death
Rna Interference
Cell Activation

Programmed Cell Death
Phagosome Formation
Tube Formation
Type I Hypersensitivity
Neurogenesis
Hypersensitivity
Vasculogenesis

PTMs

Phosphorylation

Myristoylation

Methylation

Research Areas

Lipid and Metabolism

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CERK

References

PMID: 11956206 by Sugiura M., et al. Ceramide kinase, a novel lipid kinase. Molecular cloning and functional characterization.

PMID: 16269826 by Van Overloop H., et al. Further characterization of mammalian ceramide kinase: substrate delivery and (stereo)specificity, tissue distribution, and subcellular localization studies.