CH25H Antibodies

AND CH25H ELISA kits, CH25H Proteins

Many biological assays use antibodies to detect CH25H, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CH25H in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CH25H antibodies...

We validate the specificity of these antibodies to CH25H by testing them on tissues known to express CH25H positively and negatively. Browse below to find the CH25H antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CH25H Infographic by Boster Bio

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CH25H (NM_003956) Human Over-expression Lysate

Human

$628
Cat # LS009023
20 µg, 100 µg

CH25H Overview

Facts about Cholesterol 25-hydroxylase.

CH25H 3D structure. Source: alphafold

Cholesterol 25-hydroxylase (CH25H)

Catalyzes the formation of 25-hydroxycholesterol from cholesterol, leading to repress cholesterol biosynthetic enzymes (PubMed:9852097). Plays a key role in cell placement and motion in lymphoid cells: 25-hydroxycholesterol is an intermediate in biosynthesis of 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC), an oxysterol that serves as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells.

May play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein (SREBP) processing. In testis, creation of 25-hydroxycholesterol by macrophages may play a role in Leydig cell differentiation.

Gene Information

Human
Gene Name:	CH25H
Uniprot:	O95992
Entrez:	9023

Family

Belongs to:

sterol desaturase family

Alternative Names

C25H; cholesterol 25-hydroxylase; Cholesterol 25-monooxygenase; EC 1.14.99.38; h25OH

Molecular Weight

Mass (kDA):
31.745 kDA

Genomic Context


Human

Location:	10q23.31
Sequence:	10; NC_000010.11 (89205629..89207317, complement)

Subcellular Localizations

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Diseases

Alzheimer's Disease
Inflammation
Inflammatory Response
5,10-methylenetetrahydrofolate Reductase Deficiency
Atherosclerosis
Impaired Phagocytosis
Neoplasm Metastasis
Melanoma
Neurodegenerative Disorders
Dementia
Malignant Neoplasm Of Urinary Bladder
Lung Diseases, Parasitic

Malignant Neoplasms
Neoplasms
Innate Immune Response
Nervousness
Memory Impairment
Myositis
Mild Cognitive Disorder

Pathways

Pathogenesis
Transport
Immune Response
Inflammatory Response
Cell Migration
Cell Proliferation
Regulation Of Cholesterol Homeostasis
Adaptive Immune Response
Phagocytosis
Innate Immune Response

Cell Growth
Cholesterol Transport
Wound Healing
Cholesterol Homeostasis

PTMs

Phosphorylation

Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CH25H

References

PMID: 9852097 by Lund E.G., et al. cDNA cloning of mouse and human cholesterol 25-hydroxylases, polytopic membrane proteins that synthesize a potent oxysterol regulator of lipid metabolism.

PMID: 15465627 by Riemenschneider M., et al. Association analysis of genes involved in cholesterol metabolism located within the linkage region on chromosome 10 and Alzheimer's disease.