Chromodomain-helicase-DNA-binding protein 5 (CHD5)

Chromatin-remodeling protein which binds DNA via histones and regulates gene transcription. May specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non- methylated 'Lys-4' of histone H3.

Plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 in'Lys- 27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages.