Carbohydrate sulfotransferase 8 (CHST8)

Catalyzes the transfer of sulfate to position 4 of non- reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Required for biosynthesis of glycoprotein hormones lutropin and thyrotropin, by mediating sulfation of the carbohydrate structures.

Only active against terminal GalNAcbeta1,GalNAcbeta. Not active toward chondroitin.