CIART Antibodies

AND CIART ELISA kits, CIART Proteins

Many biological assays use antibodies to detect CIART, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CIART in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CIART antibodies...

We validate the specificity of these antibodies to CIART by testing them on tissues known to express CIART positively and negatively. Browse below to find the CIART antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CIART Infographic by Boster Bio

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C1orf51 (CIART) (NM_144697) Human Over-expression Lysate

Human

$628
Cat # LS148523
20 µg, 100 µg

CIART Overview

Facts about Circadian-associated transcriptional repressor.

CIART 3D structure. Source: alphafold

Circadian-associated transcriptional repressor (CIART)

Transcriptional repressor which creates a negative regulatory component of the circadian clock also functions independently of the circadian transcriptional repressors: CRY1, CRY2 and BHLHE41. At a histone deacetylase-dependent manner represses the transcriptional activator activity of this CLOCK-ARNTL/BMAL1 heterodimer.

Abrogates the interaction of ARNTL/BMAL1 with the transcriptional coactivator CREBBP and can repress the histone acetyl-transferase action of the CLOCK-ARNTL/BMAL1 heterodimer, reducing histone acetylation of its target genes. Rhythmically binds the E-box components (5'-CACGTG-3') on circadian gene promoters and its occupancy shows circadian oscillation antiphasic to ARNTL/BMAL1.

Gene Information

Human
Gene Name:	CIART
Uniprot:	Q8N365
Entrez:	148523

Family

Belongs to:

No superfamily

Alternative Names

Circadian-associated transcriptional repressor

Molecular Weight

Mass (kDA):
41.443 kDA

Genomic Context


Human

Location:	1q21.2
Sequence:	1; NC_000001.11 (150282554..150287093)

Subcellular Localizations

Nucleus. Nucleus, PML body. Co-localizes with the CLOCK-ARNTL/BMAL1 heterodimer in the PML body.

Interacting Proteins

Arntl
DAB1
Per2

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CIART

References

PMID: 24385426 by Annayev Y., et al. Gene model 129 (Gm129) encodes a novel transcriptional repressor that modulates circadian gene expression.