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CINP Antibodies
AND CINP ELISA kits, CINP Proteins
Many biological assays use antibodies to detect CINP, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CINP in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CINP antibodies...
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CINP Infographic by Boster Bio
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CINP Overview
Facts about Cyclin-dependent kinase 2-interacting protein.
Cyclin-dependent kinase 2-interacting protein (CINP)
Interacts with the components of the replication complex and two kinases, CDK2 and CDC7, thereby providing a practical and physical connection between CDK2 and CDC7 during shooting of the origins of replication. Regulates ATR-mediated checkpoint signaling.
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Gene Information
| Human | |
|---|---|
| Gene Name: | CINP |
| Uniprot: | Q9BW66 |
| Entrez: | 51550 |
Family
| Belongs to: |
|---|
| CINP family |
Alternative Names
CDK2-interacting protein; cyclin-dependent kinase 2 interacting protein; cyclin-dependent kinase 2-interacting protein; MGC849
Molecular Weight
Mass (kDA):
24.324 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 14q32.31 |
| Sequence: | 14; NC_000014.9 (102348282..102362916, complement) |
Subcellular Localizations
Nucleus. Binds to nuclear under G1 conditions, and dissociates from chromatin with the start of DNA replication.
Diseases
- Depressive Disorder
- Anxiety Disorders
- Mental Disorders
- Schizophrenia
- Sleep Initiation And Maintenance Disorders
- Neoplasms
- Sleeplessness
- Nervousness
- Bipolar Disorder
- Cell Transformation, Neoplastic
- Neurotoxicity Syndromes
- Cholangiocarcinoma
- Polyneuropathy
Interacting Proteins
- ATR
- ATRIP
- BLZF1
- C1orf109
- CLUAP1
- GOLGA2
- REL
- SNRPD2
- SYCE1
Pathways
- Neuroprotection
- Cell Division
- Dna Replication
- Cell Proliferation
- Cell Cycle Checkpoint
- Cell Cycle
- S Phase
- Dna Repair
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CINP
bosterbio.com/bosterbio-gene-info-cards/CINP
References
PMID: 16082200 by Grishina I., et al. A novel Cdk2 interactor is phosphorylated by Cdc7 and associates with components of the replication complexes.
PMID: 19889979 by Lovejoy C.A., et al. Functional genomic screens identify CINP as a genome maintenance protein.