C-type lectin domain family 4 member A (CLEC4A)

C-type lectin receptor which binds carbohydrates mannose and fucose but also weakly interacts with N-acetylglucosamine (GlcNAc) in a Ca(2+)-dependent manner (PubMed:27015765). Involved in regulating immune reactivity (PubMed:18258799, PubMed:10438934).

Once triggered by antigen, it's internalized by clathrin-dependent endocytosis and delivers its antigenic freight to the antigen presentation pathway leading to cross-priming of CD8(+) T cells. This cross-presentation and cross-priming are enhanced by TLR7 and TLR8 agonists with increased expansion of the CD8(+) T cells, higher production of IFNG and TNF with decreased levels of IL4, IL5 and IL13 (PubMed:18258799, PubMed:20530286).