Clec9a Antibodies

AND Clec9a ELISA kits, Clec9a Proteins

Many biological assays use antibodies to detect Clec9a, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Clec9a in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Clec9a antibodies...

We validate the specificity of these antibodies to Clec9a by testing them on tissues known to express Clec9a positively and negatively. Browse below to find the Clec9a antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Clec9a Infographic by Boster Bio

All Clec9a Products

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Anti-CLEC9A Antibody

14 Q&As

IHC analysis of CLEC9A using anti-CLEC9A antibody (A04577)

Human

Flow Cytometry, IHC, ICC

$370
Cat # A04577
100 μg/vial

Anti-CD370 Purified CLEC9A Monoclonal Antibody

Flow cytometry multicolor surface staining of human myeloid cells stained using anti-human CD370 (8F9) purified antibody (concentration in sample 1,67 µg/ml, GAM FITC) and anti-human CD16 (3G8) APC antibody (10 µl reagent / 100 µl of peripheral whole blood)

Human

Flow Cytometry, ICC

$323
Cat # M04577
0.1 mg

Clec9a Overview

Facts about C-type lectin domain family 9 member A.

C-type lectin domain family 9 member A (Clec9a)

Acts as an endocytic receptor on a tiny subset of myeloid cells specialized for the uptake and processing of material from dead cells. Recognizes filamentous form of actin in association with specific actin-binding domains of cytoskeletal proteins, such as spectrin, exposed when cell membranes are damaged, and mediate the cross-presentation of dead-cell associated antigens in a Syk-dependent method.

Gene Information

Mouse
Gene Name:	Clec9a
Uniprot:	Q8BRU4
Entrez:	232414

Family

Belongs to:

No superfamily

Alternative Names

CD370; CLEC9a; C-type lectin domain family 9 member A; C-type lectin domain family 9, member A; DNGR1; HEEE9341; UNQ9341

Molecular Weight

Mass (kDA):
27.014 kDA

Genomic Context


Mouse

Location:	6\|6 F3
Sequence:	6;

Tissue Specificity

Isoform 4 expressed at high levels by CD8(+) dendritic cells (DCs), and at low levels by plasmacytoid DCs but not by other hematopoietic cells.

Diseases

Neoplasms
Melanoma
Inflammation
Neoplasm Metastasis
Malaria, Cerebral
Alphavirus Infections
Inflammatory Response
Patient Dependence On
Malignant Neoplasms
Malaria
Post-traumatic Stress Disorder
Mycoses
Stress, Psychological

Carcinoma, Lewis Lung
Diabetes, Autoimmune
Bulla
Infective Disorder
Vaccinia
Lung Neoplasms
B16 Malignant Melanoma

Pathways

Immune Response
Endocytosis
Cytokine Production
Secretion
Clathrin-mediated Endocytosis
Cell Proliferation
Dna Methylation
Cytokine Secretion
Adaptive Immune Response
Inflammatory Response
Methylation
Tolerance Induction

Receptor Internalization
Phagocytosis
Translation
Cell Death
T Cell Proliferation
Cell Recognition
Autophagy

PTMs

Glycosylation

Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Clec9a

References

PMID: 18408006 by Huysamen C., et al. CLEC9A is a novel activation C-type lectin-like receptor expressed on BDCA3+ dendritic cells and a subset of monocytes.

PMID: 18497879 by Sancho D., et al. Tumor therapy in mice via antigen targeting to a novel, DC-restricted C-type lectin.