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- Table of Contents
CLIC1 Antibodies
AND CLIC1 ELISA kits, CLIC1 Proteins
Many biological assays use antibodies to detect CLIC1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CLIC1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CLIC1 antibodies...
Designing a Western blot for CLIC1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the CLIC1 Western Blot GuideCLIC1 Infographic by Boster Bio
All CLIC1 Products
Product
Figures
Specificity
Applications
Price
Human, Monkey, Rat
ELISA, Flow Cytometry, WB
$370
Cat # A02397-1
100 μg/vial
Cat # A02397-1
100 μg/vial
CLIC1 Overview
Facts about Chloride intracellular channel protein 1.
Chloride intracellular channel protein 1 (CLIC1)
Can insert into membranes and form chloride ion channels. Channel activity depends on the pH.
Membrane insertion appears to be redox-regulated and might occur only under oxydizing conditions. Involved in regulation of the cell cycle.
Gene Information
| Human | |
|---|---|
| Gene Name: | CLIC1 |
| Uniprot: | O00299 |
| Entrez: | 1192 |
Family
| Belongs to: |
|---|
| chloride channel CLIC family |
Alternative Names
Chloride channel ABP; chloride intracellular channel 1; chloride intracellular channel protein 1; G6; hRNCC; NCC27p64CLCP; Nuclear chloride ion channel 27; nuclear chloride ion channel protein; Regulatory nuclear chloride ion channel protein; RNCC protein
Molecular Weight
Mass (kDA):
26.923 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 6p21.33 |
| Sequence: | 6; NC_000006.12 (31730581..31737318, complement) |
Tissue Specificity
Expression is prominent in heart, placenta, liver, kidney and pancreas.
Subcellular Localizations
Nucleus. Nucleus membrane; Single-pass membrane protein. Cytoplasm. Cell membrane; Single-pass membrane protein. Mostly in the nucleus including in the nuclear membrane (PubMed:9139710, PubMed:12681486). Small amount in the cytoplasm and the plasma membrane (PubMed:9139710). Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain (PubMed:11940526, PubMed:11551966, PubMed:14613939).
Diseases
- Malignant Neoplasms
- Neoplasms
- Carcinoma
- Neoplasm Metastasis
- Cell Invasion
- Neoplasm Invasiveness
- Adenocarcinoma
- Liver Carcinoma
- Alzheimer's Disease
- Liver Neoplasms
- Inflammation
- Malignant Paraganglionic Neoplasm
- Lymphatic Metastasis
Interacting Proteins
- PSMD10
Pathways
- Cell Proliferation
- Transport
- Localization
- Cell Cycle
- Cell Division
- Flight
- Phagocytosis
- Translation
- Cell Motility
- Chloride Transport
- Ion Transport
- Macrophage Activation
- Neuroprotection
PTMs
- Oxidation
- Phosphorylation
Research Areas
- Cancer
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CLIC1
bosterbio.com/bosterbio-gene-info-cards/CLIC1
References
PMID: 9139710 by Valenzuela S.M., et al. Molecular cloning and expression of a chloride ion channel of cell nuclei.
PMID: 10191309 by Chuang J.Z., et al. A 29 kDa intracellular chloride channel p64H1 is associated with large dense-core vesicles in rat hippocampal neurons.