UMP-CMP kinase Antibodies

AND CMPK1 ELISA kits, UMP-CMP kinase Proteins

Many biological assays use antibodies to detect UMP-CMP kinase, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with UMP-CMP kinase in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop UMP-CMP kinase antibodies...

We validate the specificity of these antibodies to UMP-CMP kinase by testing them on tissues known to express CMPK1 positively and negatively. Browse below to find the CMPK1 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing an IHC experiment for UMP-CMP kinase? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.

Open the CMPK1 IHC Guide

CMPK1 Infographic by Boster Bio

All CMPK1 Products

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Applications

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Anti-UMP-CMP Kinase (E36) CMPK1 Antibody

Western blot (WB) analysis of UMP-CMP Kinase (E36) pAb at 1:1000 dilution
Lane1:Hela whole cell lysate(40ug)
Lane2:H9C2 whole cell lysate(40ug)
Lane3:MEF whole cell lysate(40ug)
Lane4:A549 whole cell lysate(40ug)
Lane5:HEK293T whole cell lysate(40ug)

Immunohistochemistry (IHC) analyzes of UMP-CMP Kinase (E36) pAb in paraffin-embedded human breast carcinoma tissue at 1:100

Immunoprecipitation of HEK293T cell lysate using UMP-CMP Kinase (E36) pAb (Sepharose Bead Conjugate) #BD0048(lane 2 and lane 3) and Nonspecific IgG Control (Sepharose Bead Conjugate) #BD0048 (lane 4 and lane 5)

Human, Mouse, Rat

IP, IHC, WB

$405
Cat # A07962-1
100ul

CMPK1 (NM_016308) Human Over-expression Lysate

CMPK1 Human Over-expression Lysates NM_001136140

Human

$628
Cat # LS051727
20 µg, 100 µg

CMPK1 (NM_016308) Human Recombinant Protein

Coomassie blue staining of purified CMPK1 protein

$1249
Cat # PROTP30085
20 µg

CMPK1 Overview

Facts about UMP-CMP kinase.

CMPK1 3D structure. Source: alphafold

UMP-CMP kinase (CMPK1)

Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis.

Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity.

Gene Information

Human
Gene Name:	CMPK1
Uniprot:	P30085
Entrez:	51727

Family

Belongs to:

adenylate kinase family

Alternative Names

CMKEC 2.7.4.14; CMPKUMKUMP-CMP kinase; cytidine monophosphate (UMP-CMP) kinase 1, cytosolic; Cytidine monophosphate kinase; Cytidylate kinaseUMP/CMP kinase; Deoxycytidylate kinase; EC 2.7.4; UMP/CMPK; UMP-CMPK; UMPKUCK; Uridine monophosphate kinase; Uridine monophosphate/cytidine monophosphate kinase

Molecular Weight

Mass (kDA):
22.222 kDA

Genomic Context


Human

Location:	1p33
Sequence:	1; NC_000001.11 (47333790..47378839)

Tissue Specificity

Ubiquitously expressed.

Subcellular Localizations

Nucleus. Cytoplasm. Predominantly cytoplasmic, less than 15% nuclear.

Diseases

Malignant Neoplasms
Nervousness
Neurodegenerative Disorders
Inflammation
Malignant Neoplasm Of Pancreas
Inflammatory Response

Pathways

Inflammatory Response

PTMs

Acetylation
Isopeptide bond

Phosphoprotein
Ubl conjugation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CMPK1

References

PMID: 10462544 by Van Rompay A.R., et al. Phosphorylation of deoxycytidine analog monophosphates by UMP-CMP kinase: molecular characterization of the human enzyme.

PMID: 11681623 by Pearman A.T., et al. Characterization of human UMP-CMP kinase enzymatic activity and 5' untranslated region.