CMTR2 Infographic
Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 Info At a glance, species: Human
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Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 (CMTR2)
S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap2 2'-O-ribose methylation into the 5'-cap structure of mRNAs. Methylates the ribose of the second nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) (cap0) to produce m(7)GpppRmpNm (cap2).
Recognizes a guanosine cap on RNA independently of its N(7) methylation status. Display cap2 methylation on both cap0 and cap1.
Gene Information
| Human | |
|---|---|
| Gene Name: | CMTR2 |
| Uniprot: | Q8IYT2 |
| Entrez: | 55783 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2
Molecular Weight
Mass (kDA):
88.12 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 16q22.2 |
| Sequence: | 16; NC_000016.10 (71281392..71290178, complement) |
Subcellular Localizations
Nucleus. Cytoplasm.
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CMTR2
bosterbio.com/bosterbio-gene-info-cards/CMTR2
References
PMID: 21310715 by Werner M., et al. 2'-O-ribose methylation of cap2 in human: function and evolution in a horizontally mobile family.
PMID: 24402442 by Smietanski M., et al. Structural analysis of human 2'-O-ribose methyltransferases involved in mRNA cap structure formation.