CNGA3 Infographic
Cyclic nucleotide-gated cation channel alpha-3 Info At a glance, species: Human
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Cyclic nucleotide-gated cation channel alpha-3 (CNGA3)
Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of cone photoreceptors.
Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficiency of the station when coexpressed with CNGB3 (By similarity). Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones.
Gene Information
Human | |
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Gene Name: | CNGA3 |
Uniprot: | Q16281 |
Entrez: | 1261 |

Family
Belongs to: |
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cyclic nucleotide-gated cation channel (TC 1.A.1.5) family |

Alternative Names
CCNC1; CCNCa; CCNCalpha; CNCG3; CNG channel alpha-3; CNG-3; CNG3ACHM2; cone photoreceptor cGMP-gated channel alpha subunit; Cone photoreceptor cGMP-gated channel subunit alpha; cyclic nucleotide gated channel alpha 3; cyclic nucleotide-gated cation channel alpha-3; Cyclic nucleotide-gated channel alpha-3
Molecular Weight
Mass (kDA):
78.838 kDA

Genomic Context
Human | |
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Location: | 2q11.2 |
Sequence: | 2; NC_000002.12 (98346181..98399154) |
Tissue Specificity
Prominently expressed in retina.
Subcellular Localizations
Membrane; Multi-pass membrane protein.

Diseases
- Achromatopsia
- Color Vision Defect
- Nystagmus
- Photophobia
- Retinal Diseases
- Dystrophy
- Blind Vision
- Color Blindness
- Retinal Degeneration
- Pallor
- Rod Monochromatism
- Retinitis Pigmentosa

Pathways
- Phototransduction
- Localization
- Cell Death
- Transport
- Reflex
- Translation
- Synaptic Transmission
- Cellular Localization
- Protein Folding
- Protein Processing
- Cell Adhesion
- Cell Migration
- Protein Maturation

PTMs
- Phosphorylation

bosterbio.com/bosterbio-gene-info-cards/CNGA3
References
PMID: 9517456 by Wissinger B., et al. Cloning, chromosomal localization and functional expression of the gene encoding the alpha-subunit of the cGMP-gated channel in human cone photoreceptors.
PMID: 7532814 by Distler M., et al. Expression of cyclic nucleotide-gated cation channels in non-sensory tissues and cells.