CNOT6 Antibodies

AND CNOT6 ELISA kits, CNOT6 Proteins

Many biological assays use antibodies to detect CNOT6, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CNOT6 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CNOT6 antibodies...

We validate the specificity of these antibodies to CNOT6 by testing them on tissues known to express CNOT6 positively and negatively. Browse below to find the CNOT6 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CNOT6 Infographic by Boster Bio

All CNOT6 Products

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Price

CNOT6 (NM_015455) Human Over-expression Lysate

Human

$960
Cat # LS057472
20 µg, 100 µg

CNO6L (CNOT6L) (NM_144571) Human Over-expression Lysate

Human

$960
Cat # LS246175
20 µg, 100 µg

CNO6L (CNOT6L) (NM_144571) Human Recombinant Protein

Coomassie blue staining of purified CNOT6L protein

$1062
Cat # PROTQ96LI5
20 µg

CNOT6 Overview

Facts about CCR4-NOT transcription complex subunit 6.

CNOT6 3D structure. Source: alphafold

CCR4-NOT transcription complex subunit 6 (CNOT6)

Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and basic transcription regulation. Additional complex functions might be a result of its influence on mRNA expression.

Involved in mRNA decay mediated by the major-protein- coding determinant of instability (mCRD) of the FOS gene in the cytoplasm. In the presence of ZNF335, enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA.

Gene Information

Human
Gene Name:	CNOT6
Uniprot:	Q9ULM6
Entrez:	57472

Family

Belongs to:

CCR4/nocturin family

Alternative Names

carbon catabolite repression 4 protein; Carbon catabolite repressor protein 4 homolog; CCR4 carbon catabolite repression 4-like; CCR4CCR4-NOT transcription complex subunit 6; CCR4-NOT transcription complex, subunit 6; Cytoplasmic deadenylase; EC 3.1.13.4; KIAA1194EC 3.1

Molecular Weight

Mass (kDA):
63.307 kDA

Genomic Context


Human

Location:	5q35.3
Sequence:	5; NC_000005.10 (180494373..180578358)

Subcellular Localizations

Cytoplasm. Nucleus. Predominantly cytoplasmic.

Diseases

Malignant Neoplasms
Leukemia, Myelocytic, Acute
Myeloid Leukemia
Leukemia
Acute Lymphocytic Leukemia

Interacting Proteins

CNOT1
CNOT7
CNOT8
TNRC6C

Pathways

Cell Proliferation
Cell Death
Cell Cycle
Senescence
Translation
Regulation Of Cell Proliferation
Cell Growth

Localization
Cell Cycle Arrest

PTMs

Phosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CNOT6

References

PMID: 11747467 by Dupressoir A., et al. Identification of four families of yCCR4- and Mg2+-dependent endonuclease-related proteins in higher eukaryotes, and characterization of orthologs of yCCR4 with a conserved leucine-rich repeat essential for hCAF1/hPOP2 binding.

PMID: 11889047 by Chen J., et al. CCR4, a 3'-5' poly(A) RNA and ssDNA exonuclease, is the catalytic component of the cytoplasmic deadenylase.