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Collectin-12 Antibodies
AND COLEC12 ELISA kits, Collectin-12 Proteins
Many biological assays use antibodies to detect Collectin-12, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Collectin-12 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Collectin-12 antibodies...
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COLEC12 Infographic by Boster Bio
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COLEC12 Overview
Facts about Collectin-12.
Collectin-12 (COLEC12)
Scavenger receptor which displays several functions associated with host defense. Promotes binding and phagocytosis of Gram-positive, Gram-negative yeast and bacteria.
Mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. Binds to several carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells.
Gene Information
| Human | |
|---|---|
| Gene Name: | COLEC12 |
| Uniprot: | Q5KU26 |
| Entrez: | 81035 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
CL-P1; CLP1hCL-P1; COLEC12; collectin placenta 1; Collectin placenta protein 1; collectin sub-family member 12; collectin-12; NSR2; Nurse cell scavenger receptor 2; SCARA4; SCARA4NSR2; Scavenger receptor class A member 4; scavenger receptor class A, member 4; SRCL Type I; SRCLScavenger receptor with C-type lectin
Molecular Weight
Mass (kDA):
81.515 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 18p11.32 |
| Sequence: | 18; NC_000018.10 (316737..500701, complement) |
Tissue Specificity
Expressed in perivascular macrophages. Expressed in plaques-surrounding reactive astrocytes and in perivascular astrocytes associated with cerebral amyloid angiopathy (CAA) in the temporal cortex of Alzheimer patient (at protein level). Strongly expressed in placenta. Moderately expressed in heart, skeletal muscle, small intestine and lung. Weakly expressed in brain, colon, thymus and kidney. Expressed in nurse-like cells. Expressed in reactive astrocytes and vascular/perivascular cells in the brain of Alzheimer patient.
Subcellular Localizations
Membrane; Single-pass type II membrane protein. Forms clusters on the cell surface.
Diseases
- Reperfusion Injury
- Malignant Neoplasms
- Tissue Adhesions
- Atherosclerosis
- Disease Of Adrenal Medulla
- Melanoma
- Malignant Neoplasm Of Breast
- Hypoxia
- Carcinoma
- Injury To Kidney
- Immunologic Deficiency Syndromes
- Senile Cerebral Amyloid Angiopathy
Pathways
- Cell Adhesion
- Pathogenesis
- Cell-cell Signaling
- Cell Proliferation
- Phagocytosis
- Glycosylation
- Immune Response
PTMs
- Biotinylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/COLEC12
bosterbio.com/bosterbio-gene-info-cards/COLEC12
References
PMID: 11162630 by Nakamura K., et al. Molecular cloning and functional characterization of a human scavenger receptor with C-type lectin (SRCL), a novel member of a scavenger receptor family.
PMID: 11564734 by Ohtani K., et al. The membrane-type collectin CL-P1 is a scavenger receptor on vascular endothelial cells.