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COPS2 Antibodies
AND COPS2 ELISA kits, COPS2 Proteins
Many biological assays use antibodies to detect COPS2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with COPS2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop COPS2 antibodies...
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COPS2 Infographic by Boster Bio
All COPS2 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA
$480
Cat # EKC1759
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1759
1 kit, containing one 96-well plate and all necessary reagents
COPS2 Overview
Facts about COP9 signalosome complex subunit 2.
COP9 signalosome complex subunit 2 (COPS2)
Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes like SCF, CSA or DDB2.
The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN- dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
Gene Information
| Human | |
|---|---|
| Gene Name: | COPS2 |
| Uniprot: | P61201 |
| Entrez: | 9318 |
Family
| Belongs to: |
|---|
| CSN2 family |
Alternative Names
Alien homolog; ALIEN; COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis); COP9 signalosome complex subunit 2; CSN2JAB1-containing signalosome subunit 2; SGN2TR-interacting protein 15; Signalosome subunit 2; thyroid receptor interacting protein 15; Thyroid receptor-interacting protein 15; TRIP15TRIP-15
Molecular Weight
Mass (kDA):
51.597 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 15q21.1 |
| Sequence: | 15; NC_000015.10 (49122727..49155599, complement) |
Subcellular Localizations
Cytoplasm. Nucleus.
Diseases
- Neoplasms
- Genomic Instability
- Carcinoma
- Infective Disorder
- Congenital Absence Of Adrenal Gland
- Hypogonadotropic Hypogonadism
- Cell Transformation, Neoplastic
- Hypothyroidism
- Embryonal Carcinoma
- Rhabdomyosarcoma
- Virus Diseases
- Retinoblastoma
Interacting Proteins
- COPS3
- CREBBP
- Crebbp
- EP300
Pathways
- Cell Cycle
- Gene Silencing
- Cell Proliferation
- Dna Repair
- Senescence
- Nucleosome Assembly
- Transport
- Cellular Senescence
- Protein Targeting
- Proteolysis
- Cell Cycle Arrest
- Embryo Development
- Glial Cell Differentiation
PTMs
- Phosphorylation
- Methylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/COPS2
bosterbio.com/bosterbio-gene-info-cards/COPS2
References
PMID: 7776974 by Lee J.W., et al. Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor.
PMID: 10207062 by Dressel U., et al. Alien, a highly conserved protein with characteristics of a corepressor for members of the nuclear hormone receptor superfamily.