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Regulates activation of unfolded protein response (UPR) in the process of adaptation to ER stress in liver, by keeping translation of CPE-regulated mRNAs in conditions in which global protein synthesis is inhibited (PubMed:28092655). Required for cell cycle progression, especially for cytokinesis and chromosomal segregation (By similarity).
|RRM CPEB family|
Highly expressed in brain, including hippocampus, amygdala, granule and Purkinje cells of the cerebellum (at protein level) (PubMed:17024188, PubMed:24386439). Expressed in spinal cord (at protein level) (PubMed:27381259). Expressed in kidney, lung and heart (at protein level) (PubMed:12871996, PubMed:27381259, PubMed:24386439). Expressed in liver (at protein level) (PubMed:28092655, PubMed:12871996, PubMed:27381259, PubMed:24386439). Expressed in spleen and testis (at protein level) (PubMed:24386439, PubMed:12871996). Weakly expressed in ovary and in granular cells of dentate gyrus and the pyramidal cells of CA3 and CA1 of the hippocampus (PubMed:12871996).