Cytoplasmic polyadenylation element-binding protein 4 (Cpeb4)

Sequence-specific RNA-binding protein that binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') inside the mRNA 3'-UTR (PubMed:17024188). RNA binding causes a clear conformational change similar to the Venus fly trap mechanism (By similarity).

Regulates activation of unfolded protein response (UPR) in the process of adaptation to ER stress in liver, by keeping translation of CPE-regulated mRNAs in conditions in which global protein synthesis is inhibited (PubMed:28092655). Required for cell cycle progression, especially for cytokinesis and chromosomal segregation (By similarity).