Copine-6 Antibodies

AND CPNE6 ELISA kits, Copine-6 Proteins

Many biological assays use antibodies to detect Copine-6, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Copine-6 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Copine-6 antibodies...

We validate the specificity of these antibodies to Copine-6 by testing them on tissues known to express CPNE6 positively and negatively. Browse below to find the CPNE6 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CPNE6 Infographic by Boster Bio

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CPNE6 (NM_006032) Human Over-expression Lysate

Human

$628
Cat # LS009362
20 µg, 100 µg

CPNE6 Overview

Facts about Copine-6.

CPNE6 3D structure. Source: alphafold

Copine-6 (CPNE6)

Calcium-dependent phospholipid-binding protein which plays a role in calcium-mediated intracellular processes. Binds phospholipid membranes in a calcium-dependent manner (By similarity).

Plays a role in dendrite formation by melanocytes (PubMed:23999003). .

Gene Information

Human
Gene Name:	CPNE6
Uniprot:	O95741
Entrez:	9362

Family

Belongs to:

copine family

Alternative Names

copine VI (neuronal); Copine VI; copine-6; N-COPINE; neuronal copine; neuronal-copine

Molecular Weight

Mass (kDA):
61.991 kDA

Genomic Context


Human

Location:	14q11.2
Sequence:	14; NC_000014.9 (24069833..24078100)

Tissue Specificity

Widely expressed in the brain (PubMed:9645480, PubMed:10403379, PubMed:12949241). Expressed weakly in the kidney, liver and fetal heart (PubMed:12949241). Expressed in melanocytes (PubMed:23999003).

Subcellular Localizations

Cytoplasm. Cell membrane. Endosome. Cytoplasmic vesicle, clathrin-coated vesicle. Perikaryon. Cell projection, dendrite. Mainly cytoplasmic in absence of calcium. Associated predominantly with membranes in presence of calcium. Translocates to the cell membrane in a calcium-dependent manner. Colocalized with transferrin in intracellular clathrin-coated membrane vesicles in a calcium-dependent manner.

Interacting Proteins

MEOX2

Research Areas

Neuroscience

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CPNE6

References

PMID: 9645480 by Nakayama T., et al. N-copine: a novel two C2-domain-containing protein with neuronal activity-regulated expression.

PMID: 10403379 by Nakayama T., et al. Ca2(+)-dependent interaction of N-copine, a member of the two C2 domain protein family, with OS-9, the product of a gene frequently amplified in osteosarcoma.