Carboxypeptidase O Antibodies

AND CPO ELISA kits, Carboxypeptidase O Proteins

Many biological assays use antibodies to detect Carboxypeptidase O, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Carboxypeptidase O in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Carboxypeptidase O antibodies...

We validate the specificity of these antibodies to Carboxypeptidase O by testing them on tissues known to express CPO positively and negatively. Browse below to find the CPO antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CPO Infographic by Boster Bio

All CPO Products

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Anti-CPO Mouse Monoclonal Antibody [Clone ID: OTI1C1]

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY CPO (Right lane) cDNA for 48 hrs and lysed

HEK293T cells transfected with either CPO (Myc-DDK-tagged) overexpress plasmid (Red) or empty vector control plasmid (Blue) were immunostained by anti-CPO antibody (M03649)

Human

Flow Cytometry, WB

$523
Cat # M03649
100 µl

Anti-CPO Antibody Picoband®

Western blot analysis of CPO using anti-CPO antibody (A03649-1)

Flow Cytometry analysis of SiHa cells using anti-CPO antibody (A03649-1)

Human

ELISA, WB

$370
Cat # A03649-1
100 μg/vial

CPO (NM_173077) Human Over-expression Lysate

Human

$628
Cat # LS130749
20 µg, 100 µg

CPO Overview

Facts about Carboxypeptidase O.

CPO 3D structure. Source: alphafold

Carboxypeptidase O (CPO)

Carboxypeptidase that preferentially cleaves C-terminal acidic residues from peptides and proteins. Can also cleave C- terminal hydrophobic amino acids, with a preference for small residues over large residues.

Gene Information

Human
Gene Name:	CPO
Uniprot:	Q8IVL8
Entrez:	130749

Family

Belongs to:

peptidase M14 family

Alternative Names

carboxypeptidase O; EC 3.4.17; EC 3.4.17.-; MGC138281; MGC138283

Molecular Weight

Mass (kDA):
42.529 kDA

Genomic Context


Human

Location:	2q33.3
Sequence:	2; NC_000002.12 (206792477..206971064)

Tissue Specificity

Detected in enterocytes of the ileum.

Subcellular Localizations

Apical cell membrane; Lipid-anchor, GPI-anchor.

Diseases

Cleft Palate
Cleft Lip
Cleft Palate With Cleft Lip
Hereditary Coproporphyria
Congenital Abnormality
Neoplasms
Malignant Neoplasms
Neurotoxicity Syndromes
Porphyrias, Hepatic
Heart Failure
Nervousness

Disorders Of Porphyrin Metabolism
Cardiovascular Diseases
5,10-methylenetetrahydrofolate Reductase Deficiency
Cerebrovascular Accident
Dysequilibrium Syndrome
Obesity

Pathways

Transport
Cell Proliferation
Cell Death
Excretion
Localization
Cell Growth
Cell Differentiation
Pathogenesis
Angiogenesis
Glycosylation
Aging
Translation
Water Transport

Cell Cycle
Conjugation
Demethylation
Bone Resorption
Secretion
Cell Adhesion
Sulfide Oxidation

PTMs

Oxidation
Phosphorylation
Cleavage
Decarboxylation
Phosphorothionation
Hydroxylation
Nitration

Reduction
Glycosylation
Demethylation
Phosphorothioation
Bromination
Dephosphorylation
Iodination

Deglycosylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CPO

References

PMID: 11836249 by Wei S., et al. Identification and characterization of three members of the human metallocarboxypeptidase gene family.

PMID: 21921028 by Lyons P.J., et al. Carboxypeptidase O is a glycosylphosphatidylinositol-anchored intestinal peptidase with acidic amino acid specificity.