CRADD Infographic
Death domain-containing protein CRADD Info At a glance, species: Human
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Death domain-containing protein CRADD (CRADD)
Adapter protein that associates with PIDD1 and the caspase CASP2 to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis (PubMed:9044836, PubMed:15073321, PubMed:16652156, PubMed:17159900, PubMed:17289572). Also recruits CASP2 to the TNFR-1 signaling complex through its interaction with RIPK1 and TRADD and might play a role in the tumor necrosis factor- mediated signaling pathway (PubMed:8985253).
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Gene Information
| Human | |
|---|---|
| Gene Name: | CRADD |
| Uniprot: | P78560 |
| Entrez: | 8738 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
CASP2 and RIPK1 domain containing adaptor with death domain; Caspase and RIP adapter with death domain; caspase and RIP adaptor with death domain; CRADD; death domain containing protein CRADD; death domain-containing protein CRADD; MGC9163; RAIDD; RAIDDdeath adaptor molecule RAIDD; RIP-associated ICH1/CED3-homologous protein with death domain; RIP-associated protein with a death domain
Molecular Weight
Mass (kDA):
22.745 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 12q22 |
| Sequence: | 12; NC_000012.12 (93677342..93894840) |
Tissue Specificity
Constitutively expressed in most tissues, with particularly high expression in adult heart, testis, liver, skeletal muscle, fetal liver and kidney.
Subcellular Localizations
Cytoplasm. Nucleus.
Diseases
- Malignant Neoplasms
- Neoplasms
- Carcinoma
- Genotoxic Stress
- Denys-drash Syndrome
- Cell Transformation, Neoplastic
- Lymphoma
- Physiological Stress
- Neuroblastoma
- Malignant Squamous Cell Neoplasm
- Obesity
- Leukemia
Interacting Proteins
- ACTN2
- APPL2
- BBS5
- CASP2
- KCTD9
- PIDD1
- TRIM54
Pathways
- Cell Death
- Induction Of Apoptosis
- Localization
- Cell Cycle
- Apoptotic Process
- Cell Proliferation
- Mitochondrial Outer Membrane Permeabilization
- Response To Heat
- Cell Cycle Arrest
- Sensitization
PTMs
- Cleavage
- Sumoylation
Research Areas
- Apoptosis
- Cancer
- Cell Biology
- Tumor Suppressors
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CRADD
bosterbio.com/bosterbio-gene-info-cards/CRADD
References
PMID: 9044836 by Ahmad M., et al. CRADD, a novel human apoptotic adaptor molecule for caspase-2, and FasL/tumor necrosis factor receptor-interacting protein RIP.
PMID: 8985253 by Duan H., et al. RAIDD is a new 'death' adaptor molecule.
