Protein crumbs homolog 1 Antibodies

AND CRB1 ELISA kits, Protein crumbs homolog 1 Proteins

Many biological assays use antibodies to detect Protein crumbs homolog 1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Protein crumbs homolog 1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Protein crumbs homolog 1 antibodies...

We validate the specificity of these antibodies to Protein crumbs homolog 1 by testing them on tissues known to express CRB1 positively and negatively. Browse below to find the CRB1 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CRB1 Infographic by Boster Bio

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Anti-CRB1 Antibody Picoband®

1 Citations 5 Q&As

IHC analysis of CRB1 using anti-CRB1 antibody (A01499-1)

Human, Mouse, Rat

Flow Cytometry, IHC, WB

$370
Cat # A01499-1
100 μg/vial

CRB1 Overview

Facts about Protein crumbs homolog 1.

CRB1 3D structure. Source: alphafold

Protein crumbs homolog 1 (CRB1)

Plays a role in photoreceptor morphogenesis in the retina. May maintain cell polarization and adhesion.

Gene Information

Human
Gene Name:	CRB1
Uniprot:	P82279
Entrez:	23418

Family

Belongs to:

Crumbs protein family

Alternative Names

crumbs homolog 1 (Drosophila); LCA8

Molecular Weight

Mass (kDA):
154.183 kDA

Genomic Context


Human

Location:	1q31.3
Sequence:	1; NC_000001.11 (197201504..197478455)

Tissue Specificity

Preferential expression in retina, also expressed in brain, testis, fetal brain and fetal eye.

Subcellular Localizations

[Isoform 1]: Apical cell membrane; Single-pass type I membrane protein. Distributed at the apical membrane of all retinal epithelial cells. Located in the apical membrane of the adherens junction in outer limiting membrane (OLM) of the retina.; [Isoform 2]: Secreted.

Diseases

Amaurosis
Leber Congenital Amaurosis
Retinitis Pigmentosa
Blind Vision
Retinal Degeneration
Retinal Dystrophies
Dystrophy
Retinal Diseases
Optic Atrophy, Hereditary, Leber
Visual Impairment
Tissue Adhesions

Neoplasms
Abnormal Degeneration
Age Related Macular Degeneration
Atrophy
Night Blindness
Disorder Of Eye

Interacting Proteins

PATJ

Pathways

Localization
Pathogenesis
Cell Death
Transport
Cell Adhesion
Programmed Cell Death
Phototransduction
Pigmentation
Maintenance Of Cell Polarity
Kidney Development
Protein Targeting
Fertilization
Aging

Photoreceptor Cell Morphogenesis
Skin Development
Spermatogenesis
Eye Morphogenesis
Zonula Adherens Assembly
Phagocytosis
Long-term Memory

PTMs

Palmitoylation
Phosphorylation

Glycosylation
Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CRB1

References

PMID: 10508521 by den Hollander A.I., et al. Mutations in a human homologue of Drosophila crumbs cause retinitis pigmentosa (RP12).

PMID: 11734541 by den Hollander A.I., et al. CRB1 has a cytoplasmic domain that is functionally conserved between human and Drosophila.

1 Publications of Boster Protein crumbs homolog 1 Antibodies & ELISA Kits

PubMed ID: 31718797, Son S,Cho M,Lee J.Crumbs proteins regulate layered retinal vascular development ...

*More publications can be found for each product on its corresponding product page