CRB3 Infographic
Protein crumbs homolog 3 Info At a glance, species: Human
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Protein crumbs homolog 3 (CRB3)
Involved in the establishment of cell polarity in mammalian epithelial cells. Regulates the morphogenesis of tight junctions.
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Gene Information
| Human | |
|---|---|
| Gene Name: | CRB3 |
| Uniprot: | Q9BUF7 |
| Entrez: | 92359 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
crumbs 3; crumbs homolog 3 (Drosophila); crumbs protein homolog 3; MGC17303
Molecular Weight
Mass (kDA):
12.854 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 19p13.3 |
| Sequence: | 19; NC_000019.10 (6463777..6467221) |
Tissue Specificity
Preferentially expressed in epithelial tissues. Expressed at high levels in lung, kidney, retina, colon and mammary glands. Expressed at moderate levels in liver, spleen, pancreas, placenta and prostate.
Subcellular Localizations
Apical cell membrane; Single-pass type I membrane protein. Cell junction, tight junction. Localizes primarily to the apical membrane with a small fraction in the upper part of tight junctions of epithelial cells.
Diseases
- Neoplasms
- Retinitis Pigmentosa
- Amaurosis
- Leber Congenital Amaurosis
- Tissue Adhesions
- Neoplasm Metastasis
- Malignant Neoplasms
- Retinal Degeneration
- Cell Transformation, Neoplastic
- Tumor Progression
- Retinal Dystrophies
- Sclerosis
Interacting Proteins
- PSMA3
Pathways
- Localization
- Epithelial To Mesenchymal Transition
- Cell Adhesion
- Cell Division
- Cell Motility
- Cell-cell Adhesion
- Glycosylation
- Methylation
- Pathogenesis
- Transport
- Heterochromatin Assembly
- Cell Migration
- Gene Silencing
PTMs
- Phosphorylation
- Methylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CRB3
bosterbio.com/bosterbio-gene-info-cards/CRB3
References
PMID: 12527193 by Makarova O., et al. Mammalian Crumbs3 is a small transmembrane protein linked to protein associated with Lin-7 (Pals1).
PMID: 12771187 by Roh M.H., et al. The Crumbs3-Pals1 complex participates in the establishment of polarity in mammalian epithelial cells.