CRYM Antibodies

AND CRYM ELISA kits, CRYM Proteins

Many biological assays use antibodies to detect CRYM, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CRYM in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CRYM antibodies...

We validate the specificity of these antibodies to CRYM by testing them on tissues known to express CRYM positively and negatively. Browse below to find the CRYM antibody that suites your experiment. We have 5 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CRYM Infographic by Boster Bio

All CRYM Products

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Specificity

Applications

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Anti-CRYM Antibody

Western blot analysis of extracts of various cell lines, using CRYM antibody at 1:1000 dilution

Western blot analysis of extracts of rat brain, using CRYM antibody at 1:1000 dilution

Human, Mouse, Rat

$405
Cat # A05298
100ul

mu Crystallin (CRYM) (NM_001888) Human Recombinant Protein

Coomassie blue staining of purified CRYM protein

$1249
Cat # PROTQ14894
20 µg

Anti-mu Crystallin (CRYM) Mouse Monoclonal Antibody [Clone ID: OTI1G7]

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY CRYM (Right lane) cDNA for 48 hrs and lysed

Western blot analysis of extracts (10ug) from 10 Human tissue by using anti-CRYM monoclonal antibody at 1:200 (1: Testis; 2: Omentum; 3: Uterus; 4: Breast; 5: Brain; 6: Liver; 7: Ovary; 8: Thyroid gland; 9: colon;10: spleen)

Western blot analysis of extracts (35ug) from 9 different cell lines by using anti-CRYM monoclonal antibody

Human, Mouse, Rat

Flow Cytometry, IF, IHC, WB

$523
Cat # M05298
100 µl

mu Crystallin (CRYM) (NM_001888) Human Over-expression Lysate

mu Crystallin (CRYM) Human Over-expression Lysates NM_001014444

Human

$628
Cat # LS001428
20 µg, 100 µg

Anti-Mu Crystallin/CRYM Antibody

Human, Mouse, Rat

ELISA, Flow Cytometry, IF, IHC, WB

$370
Cat # A05298-2
100 μl/vial

CRYM Overview

Facts about Ketimine reductase mu-crystallin.

CRYM 3D structure. Source: alphafold

Ketimine reductase mu-crystallin (CRYM)

Specifically catalyzes the reduction of imine bonds in brain substrates which might include cystathionine ketimine (CysK) and lanthionine ketimine (LK). Binds thyroid hormone which is a powerful reversible inhibitor.

Presumably involved in the regulation of the free intracellular concentration of triiodothyronine and access to its nuclear receptors. .

Gene Information

Human
Gene Name:	CRYM
Uniprot:	Q14894
Entrez:	1428

Family

Belongs to:

ornithine cyclodeaminase/mu-crystallin family

Alternative Names

crystallin, mu; DFNA40NADP-regulated thyroid-hormone binding protein; mu-crystallin homolog; NADP-regulated thyroid-hormone-binding protein; THBP

Molecular Weight

Mass (kDA):
33.776 kDA

Genomic Context


Human

Location:	16p12.2
Sequence:	16; NC_000016.10 (21258521..21303062, complement)

Tissue Specificity

Expressed in neural tissue, muscle and kidney.

Subcellular Localizations

Cytoplasm.

Diseases

Complete Hearing Loss
Malignant Neoplasms
Neoplasms
Sclerosis
Primary Lateral Sclerosis
Amyotrophic Lateral Sclerosis
Muscular Dystrophy, Facioscapulohumeral
Myopathy
Malignant Neoplasm Of Prostate
Dystrophy
Prostatic Neoplasms
Muscular Dystrophy

Neoplasm Metastasis
Anterior Uveitis
Deafness Congenital
Metastatic Malignant Neoplasm To The Lymph Node
Diabetic Nephropathy
Degenerative Disorder

Interacting Proteins

TERF1

Pathways

Transport
Pathogenesis
Localization
Senescence
Ion Transport
Neurogenesis

Inflammatory Response

PTMs

Carboxylation

Research Areas

Vision

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CRYM

References

PMID: 9285773 by Segovia L., et al. Two roles for mu-crystallin: a lens structural protein in diurnal marsupials and a possible enzyme in mammalian retinas.

PMID: 9328354 by Vie M.-P., et al. Purification, molecular cloning, and functional expression of the human nicotinamide-adenine dinucleotide phosphate-regulated thyroid hormone-binding protein.