Casein kinase II subunit alpha 3 (CSNK2A3)

Probable catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a great number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Amplification-dependent oncogene; promotes cell proliferation and tumorigenesis by down- regulating expression of the tumor suppressor protein, PML.

May play a role in the pathogenesis of the lung cancer development and progression. .