Cystatin 10 Antibodies

AND Cst10 ELISA kits, Cystatin 10 Proteins

Many biological assays use antibodies to detect Cystatin 10, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Cystatin 10 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Cystatin 10 antibodies...

We validate the specificity of these antibodies to Cystatin 10 by testing them on tissues known to express Cst10 positively and negatively. Browse below to find the Cst10 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Cst10 Infographic by Boster Bio

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Cst10 Overview

Facts about Cystatin 10.

Cst10 3D structure. Source: alphafold

Cystatin 10 (Cst10)

May play a role in the last steps of the chondrocyte differentiation pathway as an inducer of maturation (PubMed:13679380). Induces chondrocyte calcification during endochondral ossification by playing a role in the transcriptional inhibition of ENPP1, a generator of pyrophosphate which inhibits calcification (PubMed:16680148).

Possibly impairs the binding of a transcription factor to the ENPP1 promoter (PubMed:16680148). Unlike other cystatins, does not have thiol protease inhibitor activity (PubMed:16680148).

Gene Information

Mouse
Gene Name:	Cst10
Uniprot:	Q9JM84
Entrez:	58214

Family

Belongs to:

cystatin family

Alternative Names

Cst10; Cystatin 10; cystatin D; Cystatin D/Cst10; DD72

Molecular Weight

Mass (kDA):
16.451 kDA

Genomic Context


Mouse

Location:	2\|2 G3
Sequence:	2;

Tissue Specificity

In cartilage, expressed mainly in mature chondrocytes including prehypertrophic and hypertrophic cells (at protein level) (PubMed:13679380). Expressed exclusively in cartilage (PubMed:11856874).

Diseases

Osteophyte
Hypertrophy
Heterotopic Ossification
Pathological Process
Fracture
Calcinosis

Degenerative Polyarthritis

Pathways

Endochondral Ossification
Ossification
Chondrocyte Differentiation

PTMs

Disulfide bond

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Cst10

References

PMID: 11856874 by Koshizuka Y., et al. Isolation of novel mouse genes associated with ectopic ossification by differential display method using ttw, a mouse model for ectopic ossification.

PMID: 13679380 by Koshizuka Y., et al. Cystatin 10, a novel chondrocyte-specific protein, may promote the last steps of the chondrocyte differentiation pathway.