CTDP1 Antibodies

AND CTDP1 ELISA kits, CTDP1 Proteins

Many biological assays use antibodies to detect CTDP1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CTDP1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CTDP1 antibodies...

We validate the specificity of these antibodies to CTDP1 by testing them on tissues known to express CTDP1 positively and negatively. Browse below to find the CTDP1 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CTDP1 Infographic by Boster Bio

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CTDP1 Overview

Facts about RNA polymerase II subunit A C-terminal domain phosphatase.

CTDP1 3D structure. Source: alphafold

RNA polymerase II subunit A C-terminal domain phosphatase (CTDP1)

Processively dephosphorylates'Ser-2' and'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit. This boosts the action of RNA polymerase II.

Plays a role in the exit from mitosis by dephosphorylating crucial mitotic substrates (USP44, CDC20 and WEE1) which are needed for M-phase-promoting factor (MPF)/CDK1 inactivation. .

Gene Information

Human
Gene Name:	CTDP1
Uniprot:	Q9Y5B0
Entrez:	9150

Family

Belongs to:

No superfamily

Alternative Names

CCFDN; CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase; CTD of POLR2A, phosphatase of, subunit 1; EC 3.1.3.16; FCP1TFIIF-associating CTD phosphatase 1; RNA polymerase II subunit A C-terminal domain phosphatase; serine phosphatase FCP1a; subunit 1; TFIIF-associating CTD phosphatase; transcription factor IIF-associating CTD phosphatase 1

Molecular Weight

Mass (kDA):
104.399 kDA

Genomic Context


Human

Location:	18q23
Sequence:	18; NC_000018.10 (79679803..79756625)

Tissue Specificity

Ubiquitously expressed.

Subcellular Localizations

Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Midbody. Found at centrosomes in prometaphase, at spindle and spindle poles in metaphase and at spindle midzone and midbody in anaphase and telophase-G1 respectively.

Diseases

Congenital Anomaly Of Face
Developmental Disabilities
Hypogonadism
Nervousness
Cytogenetic Abnormality
Charcot-marie-tooth Disease
Facial Nerve Diseases
Cataract
Peripheral Neuropathy
Marinesco-sjogren Syndrome
Bone Necrosis

Craniofacial Abnormalities
Lung Diseases
Coronary Artery Disease
Lung Diseases, Obstructive
Chronic Obstructive Airway Disease
Pulmonary Emphysema

Pathways

Pathogenesis

PTMs

Phosphorylation

Research Areas

Protein Phosphatase

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CTDP1

References

PMID: 10385623 by Cho H., et al. A protein phosphatase functions to recycle RNA polymerase II.

PMID: 9765293 by Archambault J., et al. FCP1, the RAP74-interacting subunit of a human protein phosphatase that dephosphorylates the carboxyl-terminal domain of RNA polymerase IIO.