Cullin-1 (CUL1)

Core component of multiple cullin-RING-based SCF (SKP1- CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SCF complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (PubMed:27565346).

In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. The E3 ubiquitin- protein ligase activity of the complex depends upon the neddylation of the cullin subunit and exchange of the substrate recognition element is mediated by TIP120A/CAND1.