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In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. The E3 ubiquitin- protein ligase activity of the complex depends upon the neddylation of the cullin subunit and exchange of the substrate recognition element is mediated by TIP120A/CAND1.
|Sequence:||7; NC_000007.14 (148697756..148801110)|
Expressed in lung fibroblasts.