Cullin-2 (CUL2)

Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (PubMed:27565346).

May serve as a rigid scaffold from the complex and might contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of this complex is determined by the neddylation of the cullin subunit and is inhibited by the association of this deneddylated cullin subunit with TIP120A/CAND1.