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The E3 ubiquitin- protein ligase activity of this complex is dependent upon the neddylation of the cullin subunit and is inhibited by the association of this deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the BCR complex is based upon the BTB domain-containing protein as the substrate recognition component.
|Sequence:||2; NC_000002.12 (224470150..224585397, complement)|
Brain, spermatozoa, and testis (at protein level). Widely expressed.
Nucleus. Golgi apparatus. Cell projection, cilium, flagellum. Cytoplasm, cytoskeleton, spindle. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Detected along the length of the sperm flagellum and in the cytoplasm of the germ cells (PubMed:28395323). Predominantly found in the nucleus in interphase cells, found at the centrosome at late G2 or prophase, starts accumulating at the spindle poles in prometaphase and stays on the spindle poles and the mitotic spindle at metaphase (PubMed:23213400).