Cullin-3 (CUL3)

Core component of numerous cullin-RING-based BCR (BTB- CUL3-RBX1) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme.

The E3 ubiquitin- protein ligase activity of this complex is dependent upon the neddylation of the cullin subunit and is inhibited by the association of this deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the BCR complex is based upon the BTB domain-containing protein as the substrate recognition component.