Cullin-9 (CUL9)

Core element of a Cul9-RING ubiquitin-protein ligase complex, a complex that mediates ubiquitination and subsequent degradation of BIRC5 and is required to maintain microtubule dynamics and genome integrity. Acts downstream of the 3M complex, which inhibits CUL9 activity, resulting in prevent ubiquitination of BIRC5 (PubMed:24793696).

Cytoplasmic anchor protein in p53/TP53- related protein complex. Regulates the subcellular localization of p53/TP53 and subsequent function (PubMed:12526791, PubMed:17332328).