Pre-mRNA-splicing factor CWC22 homolog Info At a glance, species: Human
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Pre-mRNA-splicing factor CWC22 homolog (CWC22)
Required for pre-mRNA splicing and for exon-junction complex (EJC) assembly. Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to advertise EJC assembly on mature mRNAs.
Through its role in EJC assembly, required for nonsense-mediated mRNA decay. .
CWC22 spliceosome-associated protein homolog (S. cerevisiae); EIF4GL; fSAPbpre-mRNA-splicing factor CWC22 homolog; KIAA1604NCMfunctional spliceosome-associated protein b; Nucampholin homolog
|Sequence:||2; NC_000002.12 (179944876..180007297, complement)|
Nucleus. Nucleus speckle. Concentrates around speckles, which are sites of pre-mRNA synthesis and processing, where it colocalizes with EJC core proteins.