CXCL6 Infographic

C-X-C motif chemokine 6 Info At a glance, species: Human

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C-X-C motif chemokine 6 (CXCL6)

Chemotactic for neutrophil granulocytes. Signals through binding and activation of its receptors (CXCR1 and CXCR2).

Besides its chemotactic and angiogenic properties, it has strong antibacterial activity against Gram-positive and Gram- negative bacteria (90-fold-higher when compared to CXCL5 and CXCL7). .

Gene Information

Human
Gene Name:	CXCL6
Uniprot:	P80162
Entrez:	6372

Family

Belongs to:

intercrine alpha (chemokine CxC) family

Alternative Names

chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2); Chemokine alpha 3; CKA-3Granulocyte chemotactic protein 2; CXCL6; GCP-2; GCP2member 6 (granulocytechemotactic protein 2); GCP-2Small-inducible cytokine B6; Small inducible cytokine subfamily B (Cys-X-Cys), member b

Molecular Weight

Mass (kDA):
11.897 kDA

Genomic Context


Human

Location:	4q13.3
Sequence:	4; NC_000004.12 (73836678..73838760)

Subcellular Localizations

Secreted.

Diseases

Inflammation
Neoplasms
Tumor Angiogenesis
Malignant Neoplasms
Inflammatory Response
Carcinoma
Cholangiocarcinoma
Neoplasm Metastasis
Tissue Adhesions
Pathologic Neovascularization
Arthritis
Osteosarcoma

Liver Carcinoma
Cell Invasion
Innate Immune Response
Rheumatoid Arthritis
Fibrosis
Chronic Inflammation
Liver Neoplasms

Interacting Proteins

CCL5
CXCL12
PF4

Pathways

Chemotaxis
Angiogenesis
Pathogenesis
Secretion
Inflammatory Response
Neutrophil Chemotaxis
Immune Response
Cell Adhesion
Chemokine Production
Cell Proliferation
Cell Migration
Innate Immune Response
Neutrophil Activation

Coagulation
Leukocyte Migration
Localization
Chemokine Secretion
Regeneration
Leukocyte Chemotaxis
Monocyte Chemotaxis

PTMs

Cleavage
Phosphorylation

Demethylation
Glycosylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CXCL6

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References

PMID: 9164944 by Rovai L.E., et al. Cloning and characterization of the human granulocyte chemotactic protein-2 gene.

PMID: 9057843 by Froyen G., et al. Cloning, bacterial expression and biological characterization of recombinant human granulocyte chemotactic protein-2 and differential expression of granulocyte chemotactic protein-2 and epithelial cell- derived neutrophil activating peptide-78 mRNAs.