C-X-C chemokine receptor type 1 (CXCR1)

Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils.

This response is mediated via a G-protein that trigger a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 using a high affinity and to MGSA (GRO) with a low affinity.