CYP2D7 Antibodies

AND CYP2D7 ELISA kits, CYP2D7 Proteins

Many biological assays use antibodies to detect CYP2D7, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CYP2D7 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CYP2D7 antibodies...

We validate the specificity of these antibodies to CYP2D7 by testing them on tissues known to express CYP2D7 positively and negatively. Browse below to find the CYP2D7 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CYP2D7 Infographic by Boster Bio

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CYP2D7 Overview

Facts about Putative cytochrome P450 2D7.

CYP2D7 3D structure. Source: alphafold

Putative cytochrome P450 2D7 (CYP2D7)

May be responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It can be involved in the metabolism of codeine into morphine (PubMed:15051713).

However, another study couldn't confirm it (PubMed:18838503). .

Gene Information

Human
Gene Name:	CYP2D7
Uniprot:	A0A087X1C5
Entrez:	1564

Family

Belongs to:

cytochrome P450 family

Alternative Names

Putative cytochrome P450 2D7

Molecular Weight

Mass (kDA):
57.489 kDA

Genomic Context


Human

Location:	22q13.2
Sequence:	22; NC_000022.11 (42139576..42144483, complement)

Tissue Specificity

Expressed in brain cortex (at protein level).

Subcellular Localizations

Membrane; Multi-pass membrane protein. Cytoplasm. Mitochondrion.

PTMs

Glycoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CYP2D7

References

PMID: 15051713 by Pai H.V., et al. A frameshift mutation and alternate splicing in human brain generate a functional form of the pseudogene cytochrome P4502D7 that demethylates codeine to morphine.

PMID: 16169517 by Gaedigk A., et al. CYP2D7 splice variants in human liver and brain: does CYP2D7 encode functional protein?