Cytochrome P450 4F2 (CYP4F2)

Omega-hydroxylase that oxidizes a number of structurally unrelated compounds, including steroids, fatty acids and xenobiotics. Plays a crucial role in vitamin K catabolism by mediating omega-hydroxylation of vitamin K1 (phylloquinone), and menaquinone-4 (MK-4), a form of vitamin K2.

Hydroxylation of phylloquinone and MK-4 probably regulates blood coagulation (PubMed:19297519, PubMed:24138531). Also shows arachidonic acid omega-hydroxylase activity in kidney, by mediating conversion of arachidonic acid into 20-hydroxyeicosatetraenoic acid (20-HETE), potentially influencing blood pressure control (PubMed:10660572, PubMed:17341693, PubMed:18574070).